Incidence of Second Primary Malignancies in Patients with Castration-Resistant Prostate Cancer: An Observational Retrospective Cohort Study in the United States
Table 3
Clinical characteristics of study cohort (N = 2,234).
Variable
No. of patients† ()
Characteristics at initial prostate cancer diagnosis
Stage (derived group)‡
Stage I or II§
543 (24.3)
Stage III
107 (4.8)
Stage IV
583 (26.1)
Unknown
1,001 (44.8)
Characteristics on or before cohort entry date
Comorbidities
Chronic pulmonary disease
947 (42.4)
Diabetes without chronic complications
920 (41.2)
Peripheral vascular disease
830 (37.2)
Cerebrovascular disease
681 (30.5)
Congestive heart failure
636 (28.5)
Mild liver disease
512 (22.9)
Renal disease
487 (21.8)
Myocardial infarction
359 (16.1)
Diabetes with chronic complications
273 (12.2)
Rheumatic disease
183 (8.2)
Peptic ulcer disease
171 (7.7)
Paraplegia and hemiplegia
87 (3.9)
Dementia
83 (3.7)
Moderate or severe liver disease
18 (0.8)
AIDS/HIV
< 11
Metastases††
Lymph node
296 (13.2)
Bone
1,797 (80.4)
Bone-directed therapy††
1,326 (59.4)
Either bone metastases or bone-directed therapy
1,887 (84.5)
Castration method
Surgical
52 (2.3)
Medical
2,106 (94.3)
Surgical and medical
76 (3.4)
Time from initial diagnosis to development of CRPC
Mean (SD), months
42.1 (32.6)
Distribution
< 6 months
89 (4.0)
6 months to 1 year
251 (11.2)
> 1 to 1.5 years
279 (12.5)
> 1.5 to 2 years
223 (10.0)
> 2 years
1,392 (62.3)
AIDS, acquired immune deficiency syndrome; HIV, human immunodeficiency virus; CRPC, castration-resistant prostate cancer; SD, standard deviation. † Unless stated otherwise. ‡ Stage according to the AJCC Staging Manual, Sixth Edition [14]. § Categories were combined to avoid reporting a count of < 11. Individual patients can have multiple comorbidities; thus, the sum of all comorbidities adds up to more than 100%. †† Recorded anytime between initial date of prostate cancer diagnosis and 30 days after the cohort entry date.