Interleukin-10 Induces Expression of Neuroendocrine Markers and PDL1 in Prostate Cancer Cells
Effect of IL10, IL6, and ENZ on PDL1 levels in PCa cells. Surface expression of PDL1 after 7 days of treatment with 50 ng/mL IL10 or IL6 and 10 µM ENZ in LNCaP (a), 16DCRPC (b), and 42DENZR (c) cells. Histograms are shown here as representative from one of three experiments. Bar graphs show mean fold MFI changes from three independent experiments (MFI of untreated cells were normalized to 1, and MFI of the samples were normalized to untreated cells). Experiments were repeated three times. The means of the MFI fold change are plotted in panel (c). The statistical significance for the difference between untreated and different treatment was determined by one-way ANOVA with Tukey’s correction. ,, and ; ns = not significant.
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