The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?

Figure 3

Hippo signaling pathway. Active Hippo signaling represses YAP and TAZ via phosphorylation (a), while inactive Hippo leads to dephosphorylation, nuclear translocation, and thus activation of TFs (b). The crossed out symbol indicates pathway members frequently lost in cancer.

(a)

(b)