Management of Patients with Nonmetastatic Castration-Resistant Prostate Cancer: Recommendations of a Multidisciplinary Panel of Experts from South America

Box 1

: Recommendations regarding the diagnosis of M0CRPC.

(i)	Conventional imaging techniques (e.g., bone scintigraphy and computed tomography of the chest and abdomen) should remain the gold standard for staging and driving therapeutic decisions in patients with M0CRPC
(ii)	Current guidance on the treatment of patients with M0CRPC does not allow making evidence-based therapeutic decisions in patients with metastasis found in exams with next-generation imaging modalities such as PSMA-PET scans that cannot be seen in conventional imaging techniques
(iii)	Although novel imaging techniques have higher sensitivity and specificity than conventional ones, there is no evidence indicating that early detection of relapse and the corresponding change in patients’ management improve survival of these patients
(iv)	Novel imaging techniques should be used for locating the disease in patients with biochemical relapse before salvage surgery or radiotherapy