Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study
Table 4
Comparison of allele frequencies of IL-6 rs1800795 and IL-8 rs2227306 SNPs in the three studied groups.
Allele frequency
Cancer versus control®
BPH versus control®
Cancer (n = 80)
BPH (n = 80)
Control (n = 80)
1
OR1 (95%CI) (LL–UL)
2
OR2 (95%CI) (LL–UL)
IL-6 rs1800795
C versus G
30 (37.5%)
43 (53.8%)
62 (77.5%)
<0.001
0.174 (0.087–0.348)
0.002
0.337 (0.170–0.669)
G versus C
50 (62.5%)
37 (46.3%)
18 (22.5%)
<0.001
5.741 (2.871–11.480)
0.002
2.964 (1.495–5.877)
IL-8 rs2227306
C versus T
41 (51.3%)
30 (37.5%)
20 (25%)
0.001
3.154 (1.615–6.161)
0.090
1.800 (0.913–3.549)
T versus C
39 (48.8%)
50 (62.5%)
60 (75%)
0.001
0.317 (0.162–0.619)
0.090
0.556 (0.282–1.095)
®: reference group, OR: odds ratio, CI: confidence interval, UL: upper limit, LL: lower limit. OR1, 1: odds ratio and p value for comparing between cancer and control. OR2, 2: odds ratio and p value for comparing between BPH and control. Statistically significant at ≤ 0.05.
