Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease
Figure 1
Delayed (48 hours post lesion) subchronic intranigral administration of 2R,4R-APDC (10 nmol in 4 L) attenuates 6-OHDA toxicity in vivo. Scatter plots showing (a) the mean percentage loss ± s.e.m of nigral TH+ cells and (b) NeuN+ cells in each treatment group (Vehicle = 10, 2R,4R-APDC, = 8). Note that 6-OHDA induces an equivalent reduction of both TH and NeuN+ cells in the SNc, which is significantly attenuated following delayed administration of 2R,4R-APDC (10 nmol). , vehicle versus 2R,4R-APDC (2-tailed students -test). (c)–(f) Representative photomicrographs (40) of DAB/peroxidase staining for TH and NeuN+ cells in the SNc from each treatment group, also showing the ROI encompassing the SNc used for cell counting, scale bar 200 m. (c) TH, 6-OHDA + vehicle, (d) NeuN,6-OHDA + vehicle, (e) TH, 6-OHDA + 2R,4R-APDC, (f) NeuN, 6-OHDA + 2R,4R-APDC.
