Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease

Table 1

Mean striatal concentrations of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) as measured by HPLC-ECD in the unlesioned and lesioned striata in each treatment group. Data shown are mean ng/mg wet weight tissue ± s.e.m. ^∗𝑃<.05, ^∗∗𝑃<.01 unlesioned versus lesioned hemisphere, ^†𝑃<.05, ^††𝑃<.01 2R,4R-APDC versus vehicle-treated animals [10]. Drug concentration in nmol (final injection volume 4 𝜇L).

Treatment group	[DA] Unlesioned ng/mL	[DA] Lesioned ng/mL	[DOPAC] Unlesioned ng/mL	[DOPAC] Lesioned ng/mL	[HVA] Unlesioned ng/mL	[HVA] Lesioned ng/mL
Vehicle	7.26 ± 0.16	1.042 ± 0.23**	1.99 ± 0.13	0.59 ± 0.15**	0.74 ± 0.07	0.33 ± 0.09**
2R,4R-APDC	7.87 ± 0.18	3.40 ± 0.54^∗∗††	1.46 ± 0.10	0.81 ± 0.07^∗∗†	0.65 ± 0.04	0.45 ± 0.06^∗∗†