Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease

Table 2

Measurement of striatal dopamine metabolism in the unlesioned and lesioned striata in each treatment group. Data are expressed as mean dopamine turnover ratio ± s.e.m calculated by the expression (DOPAC + HVA/DA) using mean pmol/mg wet weight tissue values for DA, DOPAC, and HVA, respectively. ^∗𝑃<.05, unlesioned versus lesioned hemisphere. ^†𝑃<.05, 2R,4R-APDC versus vehicle-treated animal [10]. Drug concentrations in nmol (final injection volume 4 𝜇L).

Treatment group	DA turnover ratio Unlesioned	DA turnover ratio lesioned
Vehicle	0.30 ± 0.04	0.45 ± 0.12*
2R,4R-APDC	0.26 ± 0.10	0.31 ± 0.04^∗†