Diagnostic and Pathophysiological Impact of Myocardial MIBG Scintigraphy in Parkinson's Disease

Table 1

Sensitivity and specificity of MIBG scintigraphy in Parkinson’s disease. N: total number of investigated patients in the cited study; APS: atypical Parkinsonian syndromes; Mean H & Y: arithmetical mean of Hoehn and Yahr stage of the PD patients. The strongly varying specificity may be caused by the variable distribution of the diagnoses of the patients with atypical parkinsonian syndromes. The lower norm value was calculated as mean −2.5 standard deviations (if not declared otherwise in the original papers). All data belong to the delayed imaging four hours after intravenous MIBG application.

Study	N	Patients with PD/Hoehn and Yahr stage	Patients with APS	Sensitivity	Specificity
Yoshita [36]	54	n = 25/mean H & Y = 2.1	n = 29	1.00	0.79
Orimo et al. [37]	68	n = 45/mean H & Y = 3.0	n = 23	0.80	0.87
Taki et al. [24]	70	n = 41/mean H & Y = 1.9	n = 29	0.90	0.76
Braune [14]	291	n = 246/H & Y ≥2	n = 45	0.90	0.94
Spiegel et al. [38]	102	n = 102/mean H & Y = 1,7	—	0.96	—
Sewada et al. [17]	400	n = 267/mean H & Y = 3.2	n = 133	0.84	0.89