Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice

Figure 1

Light microscopic phenotyping of cells expressing the transgene in BAsyn/PaKO mouse brains. Photomicrographs of serial, 3 𝜇m-thick sections of the spinal cord from BAsyn/PaKO mice ((a)–(h)). The syn211-immunostaining (b) colocalized with the marker GFAP (a), indicating the transgene expression in astrocytes. In the parts of the spinal cord where many Iba1-positive cells (c) are stained, it seems that only one cell could be also positive for syn211 (d), indicating that it is not clear if the hm 𝛼-syn is expressed in microglia. For MBP-immunopositive oligodendrocytes (e) and NeuN-immunopositive (g) neurons no match with syn211-immunostaining could be detected ((f), (h)). Scale bars: (a)–(d): 30 𝜇m; (e)–(h) 50 𝜇m.

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