Figure 2: Photomicrographs of tyrosine hydroxylase immuno-stained nigra of a control (a) and 6-OHDA lesioned (b) rat. Images are representative of the effect of a saline/sham microinjection (a) and 6-OHDA lesion (b) of the MFB on the SNc. The nigral DA neurons are highly TH-immunoreactive; note the lack of staining on the right side of (b), indicative of a large lesion of the dopaminergic SNc. In contrast, there is preservation of the nigra on the targeted (right) side in (a). MFB, medial forebrain bundle; SNc, substantia nigra pars compacta.