Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat
Figure 3
Behavioral parameters. (a) Apomorphine rotation test. Net contralateral turning bias recorded as number of turns made in a 30 minutes period. Apomorphine induced an overt contralateral turning bias in the 6-OHDA lesioned group, but had no effect on the pooled control group, which did not exhibit rotation (unpaired -test: , ). (b) Head position bias. There was no bias prior to MFB surgery. 6-OHDA lesions induced an ipsilateral bias in head position in contrast to pooled controls which showed no bias (head bias ANOVA: , , post hoc group difference ). . (c) Curling severity and (d) direction of bias. There was no bias at the baseline. 6-OHDA lesions induced an ipsilateral bias in curling in contrast to pooled controls which showed negligible bias (curling severity ANOVA: , ; post hoc group difference ; curling bias ANOVA: , ; post hoc group difference ). Vertical bars indicate mean ± SE of each group. BLN, baseline; MFB, medial forebrain bundle. Post Tel, posttelemetry device implantation. Wk 1, Wk 2, weeks 1 and 2 after MFB surgery, respectively. ; .
