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Parkinson’s Disease
Volume 2010 (2010), Article ID 537698, 5 pages
Research Article

Parkin Exon Rearrangements and Sequence Variants in LRRK2 Mutations Carriers: Analysis on a Possible Modifier Effect on LRRK2 Penetrance

1Centro per i Disordini del Movimento, Dipartimento di Scienze Cardiovascolari e Neurologiche, Sezione Neurologia, Università degli studi di Cagliari, Via Ospedale 46, 09124 Cagliari, Italy
2Laboratorio Centro Sclerosi Multipla, Ospedale Binaghi, Università degli studi di Cagliari, Via Is Guadazzonis, 09124 Cagliari, Italy
3Dipartimento di Scienze Cardiovascolari e Neurologiche, Policlinico Universitario, Università degli studi di Cagliari, Monserrato, 09124 Cagliari, Italy

Received 6 January 2010; Revised 6 June 2010; Accepted 14 July 2010

Academic Editor: Nobutaka Hattori

Copyright © 2010 Paolo Solla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mutations in LRRK2 represent the most common causes of Parkinson's disease (PD) identified to date, but their penetrance is incomplete and probably due to the presence of other genetic or environmental factors required for development of the disease. We analyzed the presence of parkin sequence variants (mutations or polymorphisms) and exon rearrangements in LRRK2 mutations carriers (both PD patients and unaffected relatives) in order to detect a possible modifier effect on penetrance. Eight families with nine PD patients with heterozygous LRRK2 mutations (identified within 380 Sardinian PD patients screened for the presence of the five most common LRRK2 mutations) and sixteen additional relatives were genetically investigated for the presence of LRRK2 and parkin mutations. No evidence was found for the presence of pathological parkin mutations or exon rearrangements in patients or not affected family members. Three single-nucleotide polymorphisms (SNPs) were identified both in patients and unaffected relatives but did not significantly differ between the two groups. These data provide no support to the hypothesis whereby such parkin gene mutations may be commonly implicated in possible effect on penetrance in LRRK2 mutation carriers.