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Parkinson’s Disease
Volume 2010, Article ID 836962, 6 pages
Review Article

Total Cholesterol and the Risk of Parkinson's Disease: A Review for Some New Findings

Chronic Disease Epidemiology Laboratory, Population Science, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA

Received 6 July 2009; Revised 18 September 2009; Accepted 14 October 2009

Academic Editor: Pablo Martinez-Martin

Copyright © 2010 Gang Hu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The studies on the association between serum cholesterol level and the risks of neurodegenerative diseases risk are debated. Some prospective studies have found that high serum cholesterol may increase the risks of dementia/Alzheimer's disease and ischemic stroke. However, other studies have found no association or a decreased risk of hemorrhagic stroke with increasing levels of serum total cholesterol. Little is known about the association between serum total cholesterol or a history of hypercholesterolemia and Parkinson's disease (PD) risk. Only a few case-control studies and four prospective epidemiological studies have examined this association, but the results are inconsistent. An inverse association between serum total cholesterol and the risk of PD has been found in one prospective study; however, no significant association is reported in the case-control studies and other two prospective studies. Recently, one large prospective study from Finland suggests that high total cholesterol at baseline is associated with an increased risk of PD. Further studies, especially large clinical trials, are needed.