Review Article
Neurobiology of Depression and Anxiety in Parkinson's Disease
Table 1
Depression and anxiety in pre-motor phase of PD.
| Syndrome | Reference | Prevalence | Notes |
| Depression | Schuurman et al. (2002) [13] | Hazard ratio 3.13 | The relative risk of depressed individuals developing PD | Alonso et al. (2009) [14] | Rate ratio 1.85 | The ratio of PD who initiates antidepressant therapy compared with noninitiators | Anxiety | Shiba et al. (2000) [10] | Odds ratio 2.2 | The frequency of preceding anxiety in PD compared with control subjects | Weisskopf et al. (2003) [11] | Relative risk 1.6 | Risk of PD relative to use of anxiolytic medication | Bower et al. (2010) [12] | Hazard ratio 1.63 | The relative risk of anxious personality developing PD | Depression and anxiety | Jacob et al. (2010) [15] | Odds ratio 1.42 | The frequency of receiving a diagnosis of depression or anxiety prior to PD |
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