Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease

Table 1

Comparison of representative MPTP-PD models. Each written model is representative and reproducible examples of MPTP-PD model because many researchers modify their own protocols in creating MPTP-PD model.

	Acute	Sub-acute	Chronic
Dose of MPTP	20 mg/kg	30 mg/kg	30 or 45 mg/kg/day; (using osmotic pump)
Duration of MPTP	3 or 4 times at 2 h interval	Once a day for 5 consecutive days	28 days
Administration of MPTP	i.p.	i.p.	i.p. (30 mg); s.c. (45 mg)
Extirpation of brain	7 days after injection	21 days after injection	28 days after pump infusion
Anticipating nigral cell loss	70%	40%	50%
Anticipating striatal fiber loss	90%	50%	50%
Notable features	Undesirable death (~10%)	Less or no undesirable death; Nitrated α-synuclein accumulation	Behavioral alteration; (open-field test); Formation of inclusion bodies; (stained for α-synuclein, ubiquitin); Loss of noradrenergic neurons
References	[18, 19]	[18, 20]	[18, 19, 21]