Optimizing a Rodent Model of Parkinson's Disease for Exploring the Effects and Mechanisms of Deep Brain Stimulation

Figure 2

Electrode placement in a brain slice of a rat at bregma: −3.60 mm/interaural: 5.40 mm illustrating that the insulated electrode shaft penetrates several layers of different dielectric properties, that is, the scalp, bone of skull, dura mater, subarachnoid space, and brain tissue. For unipolar lead electrodes, the counter electrode is placed subcutaneously directly on the skull at a distance of more than 20 mm. The red structure at the tip of the electrode is the STN.