Protective Role of rAAV-NDI1, Serotype 5, in an Acute MPTP Mouse Parkinson's Model
Figure 3
Analysis of mouse behavior tests 1 week after MPTP treatment. All trials were videotaped and analyzed at a later time by an observer blind to the identity of the animal. (a) For the EBS test, each animal was held 1 cm from the base of its tail and suspended approximately 1 cm above the table for 60 sec. The number of swings greater than 30° from the vertical position was counted, and the next swing was counted only after the animal passed through vertical. (b) For the drug-induced rotation test, the number of quarter turns around the bowl and the direction were used to evaluate any bias created by the protection of NDI1 when challenged with either MPTP or saline. Data are represented as mean ± SEM (MPTP Only, ; NDI1 + Saline, ; NDI1 + MPTP, ) . Light grey column, movement left; dark grey column, movement right.
