Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS: A Pilot Study

Table 1

Changes in nonmotor symptom (NMS) score from questionnaire. The left-sided group shows percent of subjects who had a positive answer in at least one of the questions in the corresponding subset. The right-sided group shows changes in NMS score as represented by the difference in total score. Improvements of NMS scores prepost-deep brain stimulation surgery were significant. Also, sleep improved prepost-DBS (𝑃=0.03).

NMS	Frequency of NMS reported			NMS Total point
	(% present)			difference
	Pre-DBS	Post-DBS	𝑃 Value*	Mean	SD	𝑃Value**
NMS-Q	—	—	—	−3.70	4.27	0.03
Gastrointestinal	100.0%	50.0%	NA	−0.80	1.14	0.09
Urinary	90.0%	90.0%	1.00	0.00	0.67	1.00
Miscellaneous	50.0%	60.0%	0.66	−0.50	1.84	0.45
Perceptual	30.0%	30.0%	1.00	0.20	0.63	0.63
Attention/memory	70.0%	60.0%	0.56	−0.10	0.62	0.81
Mood	60.0%	50.0%	0.56	−0.20	0.79	0.75
Sexual	55.6%	50.0%	1.00	−0.22	0.83	0.75
Cardiovascular/falls	80.0%	50.0%	0.18	−0.50	0.97	0.23
Sleep	100.0%	90.0%	NA	−1.60	1.84	0.03

*: 𝑃-values based on McNemar’s test.
**: 𝑃-values based on Wilcoxon signed rank sum test.