Parkinson’s Disease

Clinical Study

Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS: A Pilot Study

Table 2

Changes in nonmotor symptoms (NMS) scale. The left-sided group shows prepost-DBS change in prevalence of NMS symptoms. The right-sided group shows changes in NMS score as a difference in total score. Improvements of NMS scores pre-post deep brain stimulation surgery were significant (). Mean scores in miscellaneous symptoms () as well as cardiovascular/falls () symptoms had significant improvement. Prevalence of CV/falls was also significantly different between pre- and post-DBS.


NMS	Frequency of NMS reported			NMS total point
	(% present)			difference
	Pre-DBS	Post-DBS	value*	Mean	SD	value**

NMS-S	—	—	—	−38.50	30.94	0.01
Gastrointestinal	90.0%	60.0%	0.18	−0.30	7.33	0.93
Urinary	70.0%	80.0%	0.56	−3.30	6.11	0.14
Miscellaneous	70.0%	40.0%	0.08	−7.00	8.69	0.03
Perceptual	20.0%	20.0%	1.00	0.00	1.25	1.00
Attention/memory	70.0%	60.0%	0.56	−3.50	8.20	0.30
Mood/cognition	80.0%	70.0%	0.56	−9.30	13.78	0.09
Sexual	55.6%	60.0%	1.00	−4.78	7.29	0.13
Cardiovascular/falls	80.0%	30.0%	0.03	−1.90	2.08	0.02
Sleep/fatigue	100.0%	100.0%	NA	−8.95	13.28	0.13

*: -values based on McNemar’s test.
**: -values based on Wilcoxon signed rank sum test.