Models for LRRK2-Linked Parkinsonism

Table 1

LRRK2 in vitro cell models.

Genes	Cell type	Toxicity	Protein aggregation	Kinase activity	GTPase activity	References
WT, R1441C, Y1699C,; G2019S	HEK293T; SH-SY5Y; Primary neurons	+	ND	ND	ND	[79]
WT, I2020T	HEK293	ND	ND	+	ND	[38]
WT, G2019S, R1441C	HEK293; SH-SY5Y	ND	ND	+	ND	[39]
WT, G2019S, I2020T	Primary neuron	+	+	+	ND	[55]
WT, R1441C, Y1699C,; G2019S	SH-SY5Y	+	+	+	ND	[56]
WT, G2019S, G2019S-; K1906A, G2019S-; D1994N, G2019S-; DY2017-2018AL, WT-; K1347A, G2019S-; K1347A	HEK-293; SH-SY5Y; Primary neuron	+	ND	+	+	[57]
WT, K1906M, G2019S,; R1441C, R1441G,; I1371V, I1122V,; R1514Q, Y1699C,; G2385R, I2012T, I2020T	HEK293FT; SH-SY5Y; Primary neuron	+	ND	+	+	[60]
WT, G2019S, A2016T,; WT/A2016T,; G2019S/A2016T,; R1441C, Y1699C	HEK-293; Swiss-3T3; Human lymphoblastoid cells	ND	ND	+	ND	[80]
WT, T1343G, K1906M,; T2035A, R1398Q	HEK-293; Neuro-2a	ND	ND	−	ND	[76]
WT, R1441C/G, T1398N	HEK-293T	ND	ND	ND	+	[67]
WT, G2019S	HEK-293; Primary neuron	ND	ND	+	ND	[81]

WT: wild type; ND: not determined.