| Genes | Cell type | Toxicity | Protein aggregation | Kinase activity | GTPase activity | References |
| WT, R1441C, Y1699C, G2019S | HEK293T SH-SY5Y Primary neurons | + | ND | ND | ND | [79] |
| WT, I2020T | HEK293 | ND | ND | + | ND | [38] |
| WT, G2019S, R1441C | HEK293 SH-SY5Y | ND | ND | + | ND | [39] |
| WT, G2019S, I2020T | Primary neuron | + | + | + | ND | [55] |
| WT, R1441C, Y1699C, G2019S | SH-SY5Y | + | + | + | ND | [56] |
| WT, G2019S, G2019S- K1906A, G2019S- D1994N, G2019S- DY2017-2018AL, WT- K1347A, G2019S- K1347A | HEK-293 SH-SY5Y Primary neuron | + | ND | + | + | [57] |
| WT, K1906M, G2019S, R1441C, R1441G, I1371V, I1122V, R1514Q, Y1699C, G2385R, I2012T, I2020T | HEK293FT SH-SY5Y Primary neuron | + | ND | + | + | [60] |
| WT, G2019S, A2016T, WT/A2016T, G2019S/A2016T, R1441C, Y1699C | HEK-293 Swiss-3T3 Human lymphoblastoid cells | ND | ND | + | ND | [80] |
| WT, T1343G, K1906M, T2035A, R1398Q | HEK-293 Neuro-2a | ND | ND | − | ND | [76] |
| WT, R1441C/G, T1398N | HEK-293T | ND | ND | ND | + | [67] |
| WT, G2019S | HEK-293 Primary neuron | ND | ND | + | ND | [81] |
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