| Pathway | LRRK2 fragment | Link with LRRK2 | Method | References |
| Apoptosis | Full length | FADD | Co-IP (HEK293T cells, mouse brain) | [93] | Full length | TRADD, RIP1 | Co-IP (HEK293T cells) | [93] |
| Synaptic vesicle endocytosis | Full length LRR | Rab5b | YTH, pulldown, Co-IP | [111] |
|
MAPK signaling | Full length, COR, Kinase domain | MKK3 | Co-IP (HEK293T cells) | [72, 73] | Full length | MKK4 | Co-IP (HEK293T cells) | [72] | Full length, COR, Kinase domain | MKK6 | Co-IP (HEK293T cells), C. elegans | [72, 73] | Full length, COR, Kinase domain | MKK7 | Co-IP (HEK293T cells) | [72, 73] | Full length | JIP1–3 | Co-IP (HEK293T cells) | [74] | Full length | JIP4 | Co-IP (HEK293T cells) | [74] |
|
Chaperone machinery | Full length, Kinase domain, N-term | Hsp90 | Co-IP (HEK293T cells, mouse brain), YTH | [81, 88, 97–99] | Full length, Kinase domain, | p50CDC37 | Co-IP (HEK293T cells, mouse brain) | [38, 81] | Full length, ROC, N-term | CHIP | Co-IP (HEK293T cells, mouse brain), YTH | [98, 99] |
|
cytoskeleton | Full length, ROC | a-tubulin | pulldown | [102] | Full length, ROC | b-tubulin | Co-IP (HEK293T cells, mouse brain), pulldown | [102, 105] | Full length | EF1A | Co-purification (insect cells), Co-IP (HEK293T cells) | [113] | — | moesin | in vitro, in vivo | [59, 101] | Full length, ROC-COR | DVL1/2/3 | YTH, Co-IP (HEK293T cells) | [109] |
| | Full length | Sgg/GSK3b | Drosophila | [114] | Full length | Actin cytoskeleton proteins | QUICK, Co-IP (NIH3T3 cells) | [115] |
| Protein translation | — | 4E-BP | in vitro, Drosophila | [71, 116] |
|
PD related proteins and others | Full length, COR | Parkin | Co-IP (HEK293T cells, SH-SY5Y cells, primary neurons), | [79] | Full length | 14-3-3 isoforms | Co-IP (HEK293T cells, Swiss 3T3 cells, mouse brain, kidney, spleen) | [64–66, 80] |
|
|