| Drosophila model |
| Transgene | Loss of TH positive neurons | Lewy body | Motor deficits | Suitability for testing disease modifying therapy | Reference |
| LRRKWT, LRRKR1069C (R1441C) LRRKP1, LRRKex1 (loss-of-function line) | ND | ND | + | ND | [53] | dLRRK(−/−), dLRRK(+/−), dLRRK RNAi, dLRRK Tg, R1069G(R1441G), Y1383C(Y1699C), I1915T(I2020T) | + | ND | + | ND | [71] | dLRRKe03680, dLRRK-WT, dLRRK- I1915T, dLRRKdf | ND | ND | + | ND | [140] | WT, G2019S, Y1699C, G2385R | + | ND | + | + | [117] | hLRRK2(WT), hLRRK2(I1122V), hLRRK2(Y1699C), hLRRK2(I2020T) | + | ND | + | + | [118] | WT, G2019S | + | ND | + | ND | [141] | dLRRK-WT, dLRRK-mutant(e03680) | + | ND | ND | Maybe | [142] |
| Caenorhabditis elegans model |
| LRRK2+: lrk-1(km17), LRRK2+: lrk-1(km41), G2019S+: lrk-1(km41) LRRK2+: lin-15(765ts) R1441C+: lin-15(765ts) G2019S+: lin-15(765ts) K1347A+: lin-15(765ts) | + | ND | + | ND | [119] | wlzIs2(WT), km4, N2(WT) | ND | ND | ND | ND | [73] (Interact with MKK6) | wlzIs1(WT), wlzIs2(WT), wlzIs3(G2019S), wlzIs4(G2019S), wlzIs5(R1441C), wlzIs6(KD), wlzIs7(R1441C/KD), wlzIs2 : wlzIs4(LRRK2/DAT::GFP) | + | ND | ND | + | [143] | LGI, lrk-1(tm1898, km41); LGII, pink-1(tm1779); LGX, lqIs4 (ceh-10::gfp, lin-15(n765)), N2 | ND | ND | ND | ND | [120] (Interact with PINK1) | N2(WT), N2(G2019S) | ND | ND | ND | + | [144] | LRK-1-K1726A(hLRRK2-I2020T) LRK-1-I1877T)(hLRRK2-I2020T) | ND | ND | ND | ND | [145] (trans-Golgi network) |
| Rodent model |
| BAC(WT) | + | − | − | ND | [27] | BAC(G2019S) | ND | ND | + | ND | [146] | LRRK2R1441G BAC | + | − | + | Maybe | [147] | R1441C KI | ND | ND | +(AMPH-induced) | − | [148] | BAC(WT) BAC(G2019S) | + | ND | ND | Maybe | [149] | BAC(WT) BAC(G2019S) | + | ND | + | ND | [150] | WT, A53T, G2019S, KD, A53T/LRRK2WT, A53T/LRRK2G2019S, LRRK2−/− | ND | + | ND | ND | [103] | LRRK2 null | − | ND | ND | ND | [151] | LRRK2−/− | − | +(Kidney) | ND | ND | [122] | HSV-WTHSV-G2019SHSV-G2019S/D1994A | + | ND | ND | + | [152] | LRRK2 conditional G2019S | ND | ND | ND | Maybe | [81] (Hsp90 and LRRK2 stability) |
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