Parkinson’s Disease

Clinical Study

Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease

Table 4

Total Motor UPDRS ON and OFF medication by PD subtype ().


	PD subtype
	Tremor-dominant () mean (SD)	Akinetic rigid () mean (SD)	Mixed () mean (SD)	ANOVA value

Total Motor UPDRS ON medication	12.1 (7.8)^a	18.9 (11.4)^b	13.2 (5.1)^a	0.001
Total fMotor UPDRS OFF medication	19.3 (9.9)^a	26.9 (12.1)^b	20.9 (5.7)^a	0.001
Difference between ON and OFF	7.2 (5.1)^a	8.0 (5.4)^a	7.7 (1.9)^a	0.73
Levodopa dosage per day (mg)	551.6 (306.2)^a ()	613.6 (285.4)^a ()	569.6 (357.6)^a ()	0.54

Hoehn and Yahr–OFF medication	(%)	(%)	(%)	Chi-square -value

1	5 (15.2)	5 (3.5)	0 (0.0)	0.003
1.5	5 (15.2)	4 (2.8)	3 (16.7)
2	14 (42.4)	42 (29.6)	8 (44.4)
2.5	5 (15.2)	46 (32.4)	3 (16.7)
3	3 (9.1)	27 (19.0)	4 (22.2)
4	1 (3.0)	11 (7.8)	0 (0.0)
5	0 (0.0)	7 (4.9)	0 (0.0)

UPDRS = Unified Parkinson’s Disease Rating Scale.
*One subject excluded, because they were on MAO-B inhibitors alone.
^{a, b}Means within a row with different letters differ significantly (; pairwise t-test).