Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease

Table 1

Quantification of BrdU positive cells and layer’s volume in wild-type and transgenic rats from the olfactory bulb glomerular and granular cell layers and in the SVZ. Mean ± SEM. *𝑃<.05; ns: no statistical difference between the 2 groups. Only the number of BrdU positive cells in the glomerular layer of transgenic rats was significantly increased by 68% as compared to WT animals. Values are expressed as density per mm³ and total number of BrdU positive neurons.

	Wild-type group	Transgenic group	𝑃<.05
Glomerular layer density in mm^3	1.72×10^3±0.38×10^3	2.90×10^3±0.51×10^3	*
Glomerular layer total number	2.35×10^3±0.52×10^3	4.13×10^3±0.72×10^3	*
Granular cell layer density in mm^3	5.78×10^3±0.79×10^3	6.32×10^3±1.14×10^3	ns
Granular cell layer total number	16.6×10^3±2.28×10^3	19.27×10^3±3.48×10^3	ns
Subventricular zone total number	85.1×10^3±21.4×10^3	121×10^3±16.1×10^3	ns
Glomerular layer volume in mm^3	1.364±0.21	1.423±0.06	ns
Granular layer volume in mm^3	2.872±0.41	3.050±0.202	ns