The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5^′Untranslated-Region-Directed Translation Blockers of the Parkinson’s Alpha Synuclein Expression

Figure 6

Percent inhibition of  𝛼-synuclein/APP by posiphen compared with its metabolic analogs in primary E18 neurons (from PAC-Tg(SNCA) mice). Densitometry and quantitation of the relative levels  𝛼-synuclein/APP from western blots (β-actin standardized) after treating primary neurons with posiphen and each of its three metabolic analogs at 100 nM concentration for 48 hours.