|
| (a) Neuropsychiatric symptoms: | |
| (1) Depression | |
| (2) Anxiety | |
| (3) Apathy | |
| (4) Hallucinations, delusions, illusions | |
| (5) Delirium (may be drug induced) | |
| (6) Cognitive impairment (dementia, MCI) | |
| (7) Dopaminergic dysregulation syndrome (usually related to | |
| levodopa) | |
| (8) Impulse control disorders (related to dopaminergic drugs). | |
| (b) Sleep disorders: | |
| (1) REM sleep behaviour disorder (possible premotor | |
| symptoms) | |
| (2) excessive daytime somnolence, narcolepsy type “sleep | |
| attack” | |
| (3) restless legs syndrome, periodic leg movements | |
| (4) insomnia | |
| (5) sleep disordered breathing | |
| (6) non-REM parasomnias (confusional wandering) | |
| (c) Fatigue: | |
| (1) central fatigue (may be related to dysautonomia) | |
| (2) peripheral fatigue. | |
| (d) Sensory symptoms: | |
| (1) pain | |
| (2) olfactory disturbance | |
| (3) hyposmia | |
| (4) functional anosmia | |
| (5) visual disturbance (blurred vision, diplopia; impaired | |
| contrast-sensitivity). | |
| (e) Autonomic dysfunction: | |
| (1) bladder dysfunction (urgency, frequency, nocturia) | |
| (2) sexual dysfunction (may be drug-induced) | |
| (3) sweating abnormalities (hyperhydrosis) | |
| (4) orthostatic hypotension. | |
| (f) Gastrointestinal symptoms: | |
| (1) dribbling of saliva | |
| (2) dysphagia | |
| (3) agueusia | |
| (4) constipation | |
| (5) nausea | |
| (6) vomiting. | |
| (g) Dopaminergic drug-induced behaviour NMS: | |
| (1) hallucinations, psychosis, delusions | |
| (2) dopamine dysregulation syndrome | |
| (3) impulse control disorders. | |
| (h) Dopaminergic drug-induced other NMS: | |
| (1) ankle swelling | |
| (2) dyspnea | |
| (3) skin reactions | |
| (4) subcutaneous nodules | |
| (5) erythematous | |
| (i) Nonmotor fluctuations: | |
| (1) dysautonomia | |
| (2) cognitive/psychiatric | |
| (3) sensory/pain | |
| (4) visual blurring | |
| (j) Other symptoms: | |
| (1) weight loss | |
| (2) weight gain. | |
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