Parkinson’s Disease

Research Article

Inflammatory Pathways in Parkinson’s Disease; A BNE Microarray Study

Table 4

Twelve most consistent deregulated genes across microarray studies.
SymbolDefinitionFunctionChromosomeIlluminaGrunblatt et al. 2004 [17]Hauser et al. 2005 [12]Zhang et al. 2005 [13]Moran et al. 2006 (LSN) [14]Moran et al. 2006 (LSN) [14]Lesnick et al. 2007 [15]Cantuti-Castelvetti et al. 2007 [18]Bossers et al. 2009 [16]
ALDH1A1Aldehyde dehydrogenase 1 family, member A1Oxidation reduction9q21.13−2.97**−1.35*−2.9**−4.87*−3.42**−3.83**−3.87*−1.18**
AGTR1Angiotensin II receptor, type 1Regulation of vasoconstriction3q24−4.15**−2.1**−3.57*−3.7**−4.34**−4.34*−1.09**
ANK1Ankyrin 1, erythrocyticCytoskeleton organisation8p11.1−2.23**−1.35**−1.58**−2.34**−1.95**−1.6**
ATP8A2ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2ATP biosynthetic process13q12−2.06 **−1.19**−1.47**-1.79*−1.63**−1.34**
CBLN1Cerebellin 1 precursorSynaptic transmission16q12.1−2.90**−1.35**−2.68**−1.89**−2.34*−2.02*
ACHEAcetylcholinesterase (YT blood group)Synaptic transmission7q22−1.82**−2.08*−1.15*−2.72*−1.96*
ACOT7Acyl-CoA thioesterase 7Lipid metabolism1p36−1.79**−2.28*−1.26**−2.6*−2.04*
ACSL6Acyl-CoA synthetase long-chain family member 6Lipid metabolism5q31−2.29**−1.3*−1.53**−1.25**−1.68*
ANKZF1Ankyrin repeat and zinc finger domain containingUnknown2q351.86**1.27**1.38**1.31**1.24*
AP1G2Adaptor-related protein complex 1Vesicle-mediated transport14q11.22.11**1.38*1.36**1.18*1.32**
APBA3Amyloid beta (A4) precursor protein-binding, family A, member 3Synaptic transmission19p13.31.52**1.22*1.17*1.21*1.21*
BEX1Brain expressed, X-linked 1 (BEX1)Nervous system developmentXq21-q23; Xq22−1.75**−1.94*−1.98**−2.11**−1.7*
* ; ** .