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Parkinson’s Disease
Volume 2012, Article ID 271732, 8 pages
http://dx.doi.org/10.1155/2012/271732
Review Article

Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of -Synucleinopathies

1Division of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-0057, Japan
2Department of Physiology, Nippon Medical School, Tokyo 113-8602, Japan
3Division of Animal Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8634, Japan

Received 7 December 2011; Accepted 18 January 2012

Academic Editor: Stephane Hunot

Copyright © 2012 Kazunari Sekiyama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [37 citations]

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  • Tomasz Brudek, Kristian Winge, Tina Klitmoller Agander, and Bente Pakkenberg, “Screening of Toll-Like Receptors Expression in Multiple System Atrophy Brains,” Neurochemical Research, vol. 38, no. 6, pp. 1252–1259, 2013. View at Publisher · View at Google Scholar
  • Ming-Jia Lu, Shan-Shan Wang, and Yi Zhu, “Microglia-mediated oxidative stress injury in a mouse model of Parkinson's disease,” Chinese Journal of Tissue Engineering Research, vol. 17, no. 11, pp. 2001–2006, 2013. View at Publisher · View at Google Scholar
  • Elvira Valera, Kiren Ubhi, Michael Mante, Edward Rockenstein, and Eliezer Masliah, “Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy,” Glia, 2013. View at Publisher · View at Google Scholar
  • X. Y. Mao, N. N. Li, E. K. Tan, J. H. Zhang, X. L. Chang, R. Peng, D. M. Zhao, and Q. Liao, “MCCC1/LAMP3 reduces risk of sporadic Parkinson's disease in Han Chinese,” Acta Neurologica Scandinavica, vol. 128, no. 2, pp. 136–139, 2013. View at Publisher · View at Google Scholar
  • Sandeep Vasant More, Hemant Kumar, In Su Kim, Soo-Yeol Song, and Dong-Kug Choi, “Cellular and Molecular Mediators of Neuroinflammation in the Pathogenesis of Parkinson’s Disease,” Mediators of Inflammation, vol. 2013, pp. 1–12, 2013. View at Publisher · View at Google Scholar
  • Poonam Thakur, and Bimla Nehru, “Inhibition of Neuroinflammation and Mitochondrial Dysfunctions by Carbenoxolone in the Rotenone Model of Parkinson’s Disease,” Molecular Neurobiology, 2014. View at Publisher · View at Google Scholar
  • Claire Stevens, and Glenda Hallidaypp. 127–144, 2014. View at Publisher · View at Google Scholar
  • Rebecca A. Wilshusen, and R. Lee Mosleypp. 119–142, 2014. View at Publisher · View at Google Scholar
  • Vellareddy Anantharam, Huajun Jin, Arthi Kanthasamy, and Anumantha G. Kanthasamypp. 817–831, 2014. View at Publisher · View at Google Scholar
  • Rituraj Niranjan, “The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson's Disease: Focus on Astrocytes,” Molecular Neurobiology, vol. 49, no. 1, pp. 28–38, 2014. View at Publisher · View at Google Scholar
  • Junqiang Yan, Qizhi Fu, Liniu Cheng, Mingming Zhai, Wenjuan Wu, Lina Huang, and Ganqin Du, “Inflammatory response in Parkinson's disease,” Molecular Medicine Reports, vol. 10, no. 5, pp. 2223–2233, 2014. View at Publisher · View at Google Scholar
  • Lorraine V Kalia, Liya N. Zhu, Zhanyun Fan, Hemi Dimant, Pamela J. McLean, Suneil K Kalia, Laura Kibuuka, Darius Ebrahimi-Fakhari, Nikolaus R McFarland, and Bradley T. Hyman, “Direct detection of alpha synuclein oligomers in vivo,” Acta Neuropathologica Communications, vol. 2, no. 1, 2014. View at Publisher · View at Google Scholar
  • Carolina Cebrián, John D. Loike, and David Sulzer, “Neuroinflammation in parkinson’s disease animal models: A cell stress response or a step in neurodegeneration?,” Current Topics in Behavioral Neurosciences, vol. 22, pp. 237–270, 2014. View at Publisher · View at Google Scholar
  • Iana Calou, Mary Anne Bandeira, Wellida Aguiar-Galvão, Gilberto Cerqueira, Rafaelly Siqueira, Kelly Rose Neves, Gerly Anne Brito, and Glauce Viana, “ Neuroprotective Properties of a Standardized Extract from Myracrodruon urundeuva Fr. All. (Aroeira-Do-Sertão), as Evaluated by a Parkinson’s Disease Model in Rats ,” Parkinson's Disease, vol. 2014, pp. 1–11, 2014. View at Publisher · View at Google Scholar
  • Gerwyn Morris, and Michael Maes, “Oxidative and nitrosative stress and immune-inflammatory pathways in patients with myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS),” Current Neuropharmacology, vol. 12, no. 2, pp. 168–185, 2014. View at Publisher · View at Google Scholar
  • Daniela Herrera Moro Chao, Wouter W. Kallemeijn, Andre R. A. Marques, Marie Orre, Roelof Ottenhoff, Cindy van Roomen, Ewout Foppen, Maria C. Renner, Martina Moeton, Marco van Eijk, Rolf G. Boot, Willem Kamphuis, Elly M. Hol, Jan Aten, Hermen S. Overkleeft, Andries Kalsbeek, and Johannes M. F. G. Aerts, “Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Pro,” Plos One, vol. 10, no. 9, 2015. View at Publisher · View at Google Scholar
  • Elvira Valera, and Eliezer Masliah, “Combination therapies: The next logical Step for the treatment of synucleinopathies?,” Movement Disorders, 2015. View at Publisher · View at Google Scholar
  • J. Schapansky, J. D. Nardozzi, and M. J. Lavoie, “The Complex Relationships Between Microglia, Alpha-Synuclein, And Lrrk2 In Parkinson's Disease,” Neuroscience, vol. 302, pp. 74–88, 2015. View at Publisher · View at Google Scholar
  • Dan Chen, Xiaobo Wei, Jing Zou, Rui Wang, Xu Liu, Xiaofeng Xu, Jianjun Lu, Zhanhang Wang, Beisha Tang, Brian Wang, Kunlin Jin, and Qing Wang, “Contra-directional expression of serum homocysteine and uric acid as important biomarkers of multiple system atrophy severity: a cross-sectional study,” Frontiers In Cellular Neuroscience, vol. 9, 2015. View at Publisher · View at Google Scholar
  • Tomoya Kon, Yasuo Miki, Kunikazu Tanji, Fumiaki Mori, Masahiko Tomiyama, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Jun Utsumi, Hidenao Sasaki, and Koichi Wakabayashi, “Localization of nuclear receptor subfamily 4, group A, member 3 (NR4A3) in Lewy body disease and multiple system atrophy,” Neuropathology, 2015. View at Publisher · View at Google Scholar
  • Yue Yang, Claire Shepherd, and Glenda Halliday, “Aneuploidy in Lewy body diseases,” Neurobiology Of Aging, vol. 36, no. 3, pp. 1253–1260, 2015. View at Publisher · View at Google Scholar
  • Iva Stojkovska, Brandon M. Wagner, and Brad E. Morrison, “Parkinson's disease and enhanced inflammatory response,” Experimental Biology And Medicine, vol. 240, no. 11, pp. 1387–1395, 2015. View at Publisher · View at Google Scholar
  • Heping Zhou, “Region Specific Effects of Maternal Immune Activation on Offspring Neuroimmune Function,” Open Journal of Immunology, vol. 05, no. 02, pp. 51–63, 2015. View at Publisher · View at Google Scholar
  • Lih-Fen Lue, Tiffany M. Tang, Thomas G. Beach, Douglas G. Walker, Charles H. Adler, John N. Caviness, Marwan N. Sabbagh, Geidy E. Serrano, and Lucia I. Sue, “Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology,” Neurobiology of Aging, vol. 54, pp. 175–186, 2016. View at Publisher · View at Google Scholar
  • Dilan Athauda, and Thomas Foltynie, “The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: Mechanisms of action,” Drug Discovery Today, 2016. View at Publisher · View at Google Scholar
  • D. Athauda, and T. Foltynie, “Insulin resistance and Parkinson’s disease: a new target for disease modification?,” Progress in Neurobiology, 2016. View at Publisher · View at Google Scholar
  • Yue Guo, Xiao-Dong Zhuang, Wen-Biao Xian, Ling-Ling Wu, Ze-Na Huang, Xun Hu, Ling Chen, Xiang-Song Zhang, and Xin-Xue Liao, “Serum Klotho, vitamin D, and homocysteine in combination predict the outcomes of Chinese patients with multiple system atrophy,” CNS Neuroscience and Therapeutics, vol. 23, no. 8, pp. 657–666, 2017. View at Publisher · View at Google Scholar
  • Patrick N. Harter, Irmgard Tegeder, Georg Auburger, Jana Key, Hans-Hermann Hoepken, Bastian Roller, David Meierhofer, Sylvia Torres-Odio, Michel Mittelbronn, Suzana Gispert, Júlia Canet-Pons, Lucie Valek, Michael Walter, and Blas Morales-Gordo, “Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation,” Journal of Neuroinflammation, vol. 14, no. 1, 2017. View at Publisher · View at Google Scholar
  • Alfredo Gorio, Toniella Giallongo, Cristina Viaggi, Elisa Latorre, Zuzana Gombalova, Massimiliano Mazza, Francesca Vaglini, Stephana Carelli, Andrea Raspa, and Anna Maria Di Giulio, “Recovery from experimental parkinsonism by intrastriatal application of erythropoietin or EPO-releasing neural precursors,” Neuropharmacology, vol. 119, pp. 76–90, 2017. View at Publisher · View at Google Scholar
  • Neha Sharma, and Bimla Nehru, “Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson’s disease model,” Inflammopharmacology, 2017. View at Publisher · View at Google Scholar
  • Sulzer, and Cebriánpp. 245–279, 2017. View at Publisher · View at Google Scholar
  • Najiba Mammadova, Corey M. Summers, Robyn D. Kokemuller, Qing He, Shaowei Ding, Thierry Baron, Chenxu Yu, Rudy J. Valentine, Donald S. Sakaguchi, Anumantha G. Kanthasamy, Justin J. Greenlee, and M. Heather West Greenlee, “Accelerated accumulation of retinal α-synuclein (pSer129) and tau, neuroinflammation and autophagic dysregulation in a seeded mouse model of Parkinson's disease,” Neurobiology of Disease, 2018. View at Publisher · View at Google Scholar
  • Youwen Zhang, Lijuan Wang, Yan Li, Rong Gan, Limin Wang, Bing Li, Yuhu Zhang, Shujun Feng, Kun Nie, Yuyuan Gao, and Xuegang Sun, “TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease,” Biochemical and Biophysical Research Communications, vol. 499, no. 4, pp. 797–802, 2018. View at Publisher · View at Google Scholar
  • Eric Wildon Kostuk, Jingli Cai, and Lorraine Iacovitti, “Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson’s disease,” Journal of Neuroinflammation, vol. 15, no. 1, 2018. View at Publisher · View at Google Scholar
  • Ryosuke Kojima, Daniel Bojar, Giorgio Rizzi, Kelly R. Tan, Marie Daoud El-Baba, Pratik Saxena, Martin Fussenegger, Ghislaine Charpin-El Hamri, and Simon Ausländer, “Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson's disease treatment,” Nature Communications, vol. 9, no. 1, 2018. View at Publisher · View at Google Scholar
  • Victor Bodart-Santos, Fernanda G. De Felice, Sergio T. Ferreira, and Andre F. Batista, “Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer’s and Parkinson’s Diseases,” CNS Drugs, 2018. View at Publisher · View at Google Scholar
  • Jeffrey H. Kordower, Kalipada Pahan, Kathleen M. Shannon, Robin M. Voigt, Phillip A. Engen, Hemraj B. Dodiya, Ali Keshavarzian, Christopher B. Forsyth, Jinal Patel, Maliha Shaikh, Stefan J. Green, Ankur Naqib, and Avik Roy, “Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease,” Neurobiology of Disease, 2019. View at Publisher · View at Google Scholar