Figure 1: Characterization of glial activation in a P123H S tg mouse and an S/P123H S bigenic mouse.(a) Concomitant with P123H S-positive dot-like axonal accumulation (upper), GFAP-positive reactive astrocytes were observed in the hippocampus of a P123H S tg mouse, but not in a wild-type mouse (lower). Scale . (b) Immunostaining with anti-CD11b antibody showed microglial activation in an S/P123H S bigenic mouse, but not in a wild-type mouse. Scale . The figures in (a) and (b) were reprinted from Fujita et al., [28], with permission, or are unpublished data related to the same paper.