L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain

<table>Accumulation of ASP<sup>+</sup>, the fluorescent substrate for high-affinity monoamine transporters and organic cation transporters in astrocytes in hippocampal brain slices. (a) Astrocytes current response to voltage step protocol application reveals a linear IV-relationship. (b) Puff-application of ASP<sup>+</sup> elicited transporter current in astrocytes, maintained previously at zero current. Arrow indicates the moment of application. (c) and (d) The same astrocyte with attached patch-pipette before (in (c), infrared DIC) and after (in (d), fluorescence) the application of 50 <i>μ</i>M ASP<sup>+</sup>. Scale on (c) and (d) 20 <i>μ</i>m.</table>

Parkinson’s Disease

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Figure 2

Figure 2: L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain 