A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease
Domain structure and PD mutations of LRRK2. The central region of LRRK2 contains a GTPase domain also called (ROC), a C-terminal of ROC (COR) domain of unknown function, and a kinase domain, flanked on either side by protein-protein interaction domains including an ankyrin repeat domain (ANK), leucine-rich repeats (LRR) and a WD40 domain (WD40). Clearly causative pathogenic mutations are indicated and are clustered around the catalytic domains of LRRK2. Only the G2019S mutation consistently augments kinase activity.