The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease

Table 1

Functions of known and predicted mitochondrial DUBs.

DUB	Function(s)	Reference(s)
Ataxin-3	Protein quality control; mitophagy; neuroprotective properties	[68, 70–72]
USP9x	Cell differentiation and survival; synaptic function	[63, 65]
USP30	Mitochondrial membrane dynamics	[59]
USP36	Nucleolar structure and function; oxidative stress	[61, 62]
JOSD1	Unknown
USP2	NF-kappaB signalling; AIF-mediated cell death	[73, 74]
USP16	Histone deubiquitination; gene expression	[75]
USP29	Oxidative stress	[76]
USP44	Cell cycle regulation	[50]
USP50	Cell cycle regulation	[77]