Parkinson’s Disease / 2012 / Article / Tab 2

Research Article

Adenosine A 𝟐 A Receptor Antagonists Do Not Disrupt Rodent Prepulse Inhibition: An Improved Side Effect Profile in the Treatment of Parkinson's Disease

Table 2

Mean startle magnitude ± SEM in mouse prepulse inhibition (* versus vehicle).

DrugDose (mg/kg)Startle

SCH 412348Veh.129.0 ± 17.8
0.3144.6 ± 17.8
1.0140.5 ± 20.7
3.0142.6 ± 12.9

IstradefyllineVeh.125.9 ± 22.3
0.1104.9 ± 17.3
0.3110.9 ± 19.0
1.075.9 ± 10.7

PramipexoleVeh.95.6 ± 8.7
0.3103.1 ± 13.2
1.076.3 ± 8.5
3.069.5 ± 10.5

PergolideVeh.135.2 ± 23.5
0.1149.9 ± 12.3
0.3116.9 ± 17.6
1.0100.5 ± 15.1
3.062.7 ± 10.9*

RopiniroleVeh.135.9 ± 19.7
3.0134.1 ± 15.2
10.0143.3 ± 15.6
30.0140.6 ± 18.0

L-dopaVeh.130.5 ± 20.9
10.0135.0 ± 16.4
30.096.8 ± 14.4
100.069.0 ± 5.8*
300.050.7 ± 9.6*

ApomorphineVeh.149.9 ± 26.4
0.393.1 ± 15.9
1.090.6 ± 15.2
3.094.7 ± 13.5

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.