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Parkinson’s Disease
Volume 2012, Article ID 640707, 8 pages
Research Article

Impact of Anxiety on Quality of Life in Parkinson's Disease

Department of Psychology, Boston University, Boston, MA 02215, USA

Received 15 June 2011; Revised 28 August 2011; Accepted 29 August 2011

Academic Editor: Antonio Lucio Teixeira

Copyright © 2012 Kristine K. Hanna and Alice Cronin-Golomb. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In Parkinson's disease (PD), both the patient and the health care provider look for ways to preserve the patient's quality of life. Many studies focus on the impact of depression and motor disability on poor life quality but neglect to examine the role of anxiety. We investigated the impact of anxiety and depression on health-related quality of life in PD, using the Parkinson's Disease Quality of Life measure (PDQ-39). Symptoms of anxiety, more than depression, cognitive status, or motor stage, significantly affected quality of life in 38 nondemented patients with mild-to-moderate motor disability. Stepwise regression analyses revealed that anxiety explained 29% of the variance in the PDQ-39 sum score, and depression explained 10% of the variance beyond that accounted for by anxiety. The findings suggest that primary management of anxiety as well as depression may be important to optimizing the quality of life of PD patients.