Improved Dynamic Postural Task Performance without Improvements in Postural Responses: The Blessing and the Curse of Dopamine Replacement

Table 2

FGA item analysis: items were determined to be dopamine responsive if 3 criteria were met: (1) there was statistical significance between medication conditions, (𝑃<0.005) (2) there was a large effect size (ES > 0.70), and (3) the majority of individuals tested demonstrated a performance improvement with dopamine replacement.

FGA Item	Between-medication condition significance level	Between-medication condition effect size	Number with positive dopamine-replacement effect	Dopamine-responsive (Yes/No)
(1) Gait on a level surface	𝑃<0.002	1.07	9/15	Yes
(2) Change in gait speed	𝑃<0.004	1.03	8/15	Yes
(3) Gait with horizontal head turns	𝑃<0.017	0.63	5/15	No
(4) Gait with sustained vertical head positions	𝑃<0.003	0.85	7/15	No
(5) Gait and pivot turn	𝑃<0.017	0.65	7/15	No
(6) Step over obstacle	𝑃<0.090	0.31	2/15	No
(7) Gait with narrow base of support	𝑃<0.003	0.90	9/15	Yes
(8) Gait with eyes closed	𝑃<0.048	0.47	5/15	No
(9) Ambulating backwards	𝑃<0.017	0.75	7/15	No
(10) Steps	𝑃<0.080	0.32	2/15	No