The Protective Effect of Minocycline in a Paraquat-Induced Parkinson's Disease Model in Drosophila is Modified in Altered Genetic Backgrounds
MC blocks the changes induced by PQ in the DA and BH4 biosynthesis pathways. (a) Changes in the DA and BH4 metabolites in adult males exposed to 10 mM PQ or 10 mM PQ with 1 mM MC for 24 hrs. The increase in L-DOPA levels, indicative of PQ-stimulated TH activity, is reduced by MC. (b) The DA metabolite, DOPAC, is elevated by PQ exposure and is significantly decreased by the co-feeding of MC to male adults for 24 hr. (c) The compensatory increase in GTPCH activity in PQ-fed adult males is reduced in PQ-MC co-fed males at 24 hr of ingestion. The significance of differences in each subset between the PQ-treated and control groups, and PQ-treated and co-fed groups is indicated as * and #, respectively, where * and # = and ** and ## = . Error bars represent the standard error of the mean. Each data point represents at least 10 replications of 15 flies each.