The Protective Effect of Minocycline in a Paraquat-Induced Parkinson's Disease Model in Drosophila is Modified in Altered Genetic Backgrounds
MC reduces PQ-generated reactive oxygen species. (a) The level of lipid peroxidation product was determined in head extracts of males that had ingested PQ or PQ with MC for 24 hr. MC significantly decreases the amount of lipid peroxidation induced by PQ. (b) MC reduces the specific activity of catalase after 24 hr of ingestion in co-fed male flies. The significance of differences between the PQ-treated and control groups and between the PQ-treated and co-fed groups was indicated as * and #, respectively, where * and # = . Error bars represent standard error of the mean. The experiments were done as 5–8 replicas of 10 head extracts.