17𝜶-Ethynyl-androst-5-ene-3𝜷,7𝜷,17𝜷-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease

Figure 2

HE3286 effect on motor impairment in experiments 1–3 combined. Mice (male, C57/Bl6 mice, 8 per group) were given four injections of 20 mg/kg MPTP 2 h apart. L-DOPA (24.8 mg/kg i.p.) and L-DOPA (i.p.) in combination with HE3286 (40 mg/kg gavage) were administered for 4 d beginning 1 h prior to MPTP, or HE3286 (40 mg/kg), vehicle or saline was administered by gavage twice daily for four consecutive days beginning 1 h after the last MPTP injection. Motor impairment was measured using the rotorod test (A, P < 0.0001 compared to vehicle, B, P = 0.0016, C, P = 0.0031).