17𝜶-Ethynyl-androst-5-ene-3𝜷,7𝜷,17𝜷-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease

Figure 4

HE3286 decreased MPTP-induced neuronal damage. Mice (male, C57/Bl6 mice, 8 per group) were given four injections of 20 mg/kg MPTP 2 h apart. HE3286 (40 mg/kg), vehicle or saline was administered by oral gavage twice daily for four consecutive days beginning 1 h after the last MPTP injection. Sections from fixed brain segments from four randomly selected animals per group were stained with H&E and the numbers of damaged neurons per field were counted. *Significant compared to MPTP + vehicle by the Mann-Whitney exact test.