17𝜶-Ethynyl-androst-5-ene-3𝜷,7𝜷,17𝜷-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease

Table 1

ANOVA showed a significant effect overall (Kruskal-Wallis, 𝑃=0.0003). Dunn’s post hoc test indicated significance for MPTP + HE3286 and MPTP +L-DOPA compared to MPTP + vehicle, 𝑃<0.0001 and 𝑃<0.05, respectively. There was no improvement with MPTP + HE3286 + L-DOPA compared to MPTP + L-DOPA (𝑃>0.05 by the Mann-Whitney test).

Group	𝑛		Mean rotarod; latency (sec)	SD	95% CI	𝑃 versus; MPTP + vehicle^a
	Expts	Mice
Saline	3	24	180	0	180-180
MPTP	3	19	59.2	27.3	46–72
MPTP + vehicle	3	22	58.2	27.5	46–70
MPTP + HE3286	3	21	90.9	18.4	83–99	0.0001
MPTP + L-DOPA	2	15	83.8	10.6	78–90	0.05
MPTP + L-DOPA + HE3286	2	13	84.0	12.5	76–92

^aDunn’s post hoc test.