Restless Legs Syndrome and Its Associated Risk Factors in Parkinson’s Disease
Table 2
Comparison of PD patients with and without RLS.
RLS,
No RLS,
P value
Age, years
59 (50–66)
66.5 (59–72)
0.066
Age of PD onset, years
52 (47–60)
61 (54–66.3)
0.023
Gender, n (%)
Male
9 (15)
51 (85)
0.045
Female
2 (3.8)
51 (96.2)
Ethnicity, n (%)
Malay
3 (9.7)
28 (90.3)
0.991
Chinese
7 (9.7)
65 (90.3)
Indian
1 (9.7)
7 (87.5)
Others
0 (0)
2 (100)
Duration of illness of PD, years
4 (1–9)
5 (2–8)
0.876
Hoehn and Yahr stage
2 (1-2)
2 (2-3)
0.014
MMSE
30 (29-30)
28 (24–30)
0.004
Levodopa, mg
390 (750)
300 (442.5)
0.988
Dopamine agonist (LEU), mg
100 (150)
0 (50)
0.098
Total LEU, mg
390 (700)
350 (457)
0.666
Serum ferritin, ng/mL
108.3 (55.7–193.4)
131.5 (72.3–206.6)
0.616
Transferrin saturation, %
34.2 (20.2–42.1)
26.3 (21.6–32.2)
0.483
Haemoglobin, g/dL
13.4 (12.6–15.3)
13.3 (12.4–14.2)
0.399
Serum iron, ug/dL
15.4 (11.5–23.6)
13.0 (11.1–15.5)
0.132
TIBC, %
56 (47–57)
48.5 (44–54)
0.108
RLS severity, n (%)
None
102 (90.3)
Mild
4 (3.5)
Moderate
4 (3.5)
Severe
3 (2.7)
Very severe
0 (0)
Data is expressed as median (IQR) unless stated otherwise. MMSE: mini mental state examination (range of score 0–30); PD: Parkinson’s disease; RLS: restless leg syndrome; TIBC: total iron binding capacity; LEU: levodopa equivalence unit; total LEU: levodopa plus LEU of dopamine agonist.
