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Parkinson’s Disease
Volume 2013, Article ID 751925, 9 pages
http://dx.doi.org/10.1155/2013/751925
Clinical Study

Repetitive Transcranial Magnetic Stimulation Improves Handwriting in Parkinson’s Disease

1Graduate Program in Rehabilitation Sciences, University of British Columbia, 212-2177 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
2Department of Physiology, University of Arizona, McKale Center 229C, P.O. Box 210096, Tucson, AZ 85721, USA
3Department of Physical Therapy, University of British Columbia, 212-2177 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3

Received 15 February 2013; Accepted 25 March 2013

Academic Editor: Gammon M. Earhart

Copyright © 2013 Bubblepreet Kaur Randhawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. L. Teulings and G. E. Stelmach, “Control of stroke size, peak acceleration, and stroke duration in Parkinsonian handwriting,” Human Movement Science, vol. 10, no. 2-3, pp. 315–334, 1991. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Flash, E. Henis, R. Inzelberg, and A. D. Korczyn, “Timing and sequencing of human arm trajectories: normal and abnormal motor behaviour,” Human Movement Science, vol. 11, no. 1-2, pp. 83–100, 1992. View at Publisher · View at Google Scholar · View at Scopus
  3. M. G. Longstaff, P. R. Mahant, M. A. Stacy, A. W. A. Van Gemmert, B. C. Leis, and G. E. Stelmach, “Discrete and dynamic scaling of the size of continuous graphic movements of parkinsonian patients and elderly controls,” Journal of Neurology Neurosurgery and Psychiatry, vol. 74, no. 3, pp. 299–304, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. A. W. A. Van Gemmert, H. L. Teulings, and G. E. Stelmach, “Parkinsonian patients reduce their stroke size with increased processing demands,” Brain and Cognition, vol. 47, no. 3, pp. 504–512, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. O. Tucha, L. Mecklinger, J. Thome et al., “Kinematic analysis of dopaminergic effects on skilled handwriting movements in Parkinson's disease,” Journal of Neural Transmission, vol. 113, no. 5, pp. 609–623, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Desmurget, S. T. Grafton, P. Vindras, H. Gréa, and R. S. Turner, “The basal ganglia network mediates the planning of movement amplitude,” European Journal of Neuroscience, vol. 19, no. 10, pp. 2871–2880, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. J. L. Contreras-Vidal and G. E. Stelmach, “A neural model of basal ganglia-thalamocortical relations in normal and parkinsonian movement,” Biological Cybernetics, vol. 73, no. 5, pp. 467–476, 1995. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Eckert, T. Peschel, H. J. Heinze, and M. Rotte, “Increased pre-SMA activation in early PD patients during simple self-initiated hand movements,” Journal of Neurology, vol. 253, no. 2, pp. 199–207, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Buhmann, V. Glauche, H. J. Stürenburg, M. Oechsner, C. Weiller, and C. Büchel, “Pharmacologically modulated fMRI—cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients,” Brain, vol. 126, no. 2, pp. 451–461, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. A. O. Ceballos-Baumann, H. Boecker, P. Bartenstein et al., “A positron emission tomographic study of subthalamic nucleus stimulation in Parkinson disease: enhanced movement-related activity of motor-association cortex and decreased motor cortex resting activity,” Archives of Neurology, vol. 56, no. 8, pp. 997–1003, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Haslinger, P. Erhard, N. Kämpfe et al., “Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa,” Brain, vol. 124, no. 3, pp. 558–570, 2001. View at Google Scholar · View at Scopus
  12. M. Jahanshahi, I. H. Jenkins, R. G. Brown, C. D. Marsden, R. E. Passingham, and D. J. Brooks, “Self-initiated versus externally triggered movements—I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects,” Brain, vol. 118, no. 4, pp. 913–933, 1995. View at Google Scholar · View at Scopus
  13. I. H. Jenkins, W. Fernandez, E. D. Playford et al., “Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomorphine,” Annals of Neurology, vol. 32, no. 6, pp. 749–757, 1992. View at Publisher · View at Google Scholar · View at Scopus
  14. E. D. Playford, I. H. Jenkins, R. E. Passingham, J. Nutt, R. S. J. Frackowiak, and D. J. Brooks, “Impaired mesial frontal and putamen activation in Parkinson's disease: a positron emission tomography study,” Annals of Neurology, vol. 32, no. 2, pp. 151–161, 1992. View at Google Scholar · View at Scopus
  15. O. Rascol, U. Sabatini, F. Chollet et al., “Normal activation of the supplementary motor area in patients with Parkinson's disease undergoing long-term treatment with levodopa,” Journal of Neurology Neurosurgery and Psychiatry, vol. 57, no. 5, pp. 567–571, 1994. View at Google Scholar · View at Scopus
  16. M. Hamada, Y. Ugawa, S. Tsuji et al., “High-frequency rTMS over the supplementary motor area for treatment of Parkinson's disease,” Movement Disorders, vol. 23, no. 11, pp. 1524–1531, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Tanji, K. Taniguchi, and T. Saga, “Supplementary motor area: neuronal response to motor instructions,” Journal of Neurophysiology, vol. 43, no. 1, pp. 60–68, 1980. View at Google Scholar · View at Scopus
  18. A. W. A. Van Gemmert, H. L. Teulings, J. L. Contreras-Vidal, and G. E. Stelmach, “Parkinson's disease and the control of size and speed in handwriting,” Neuropsychologia, vol. 37, no. 6, pp. 685–694, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. A. P. Strafella, T. Paus, J. Barrett, and A. Dagher, “Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus,” The Journal of Neuroscience, vol. 21, no. 15, p. RC157, 2001. View at Google Scholar · View at Scopus
  20. A. P. Strafella, T. Paus, M. Fraraccio, and A. Dagher, “Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex,” Brain, vol. 126, no. 12, pp. 2609–2615, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. K. Ji, J. C. Eun, Y. L. Won et al., “Therapeutic effect of repetitive transcranial magnetic stimulation in Parkinson's disease: analysis of [11C] raclopride PET study,” Movement Disorders, vol. 23, no. 2, pp. 207–211, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. H. L. Teulings, J. L. Contreras-Vidal, G. E. Stelmach, and C. H. Adler, “Parkinsonism reduces coordination of fingers, wrist, and arm in fine motor control,” Experimental Neurology, vol. 146, no. 1, pp. 159–170, 1997. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Picard and P. L. Strick, “Motor areas of the medial wall: a review of their location and functional activation,” Cerebral Cortex, vol. 6, no. 3, pp. 342–353, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. J. G. Colebatch, M. P. Deiber, R. E. Passingham, K. J. Friston, and R. S. J. Frackowiak, “Regional cerebral blood flow during voluntary arm and hand movements in human subjects,” Journal of Neurophysiology, vol. 65, no. 6, pp. 1392–1401, 1991. View at Google Scholar · View at Scopus
  25. E. M. Wassermann, “Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5–7, 1996,” Electroencephalography and Clinical Neurophysiology, vol. 108, no. 1, pp. 1–16, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. A. W. A. Van Gemmert, C. H. Adler, and G. E. Stelmach, “Parkinson's disease patients undershoot target size in handwriting and similar tasks,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 74, no. 11, pp. 1502–1508, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. E. V. Evarts and S. P. Wise, “Basal ganglia outputs and motor control,” Ciba Foundation Symposium, vol. 107, pp. 83–102, 1984. View at Google Scholar · View at Scopus
  28. K. E. Martin, J. G. Phillips, R. Iansek, and J. L. Bradshaw, “Inaccuracy and instability of sequential movements in Parkinson's disease,” Experimental Brain Research, vol. 102, no. 1, pp. 131–140, 1994. View at Google Scholar · View at Scopus
  29. J. Nolte, The Human Brain: An Introduction to Its Functional Anatomy, Mosby, St. Louis, Mo, USA, 4th edition, 1999.
  30. R. Romo and W. Schultz, “Role of primate basal ganglia and frontal cortex in the internal generation of movements. III. Neuronal activity in the supplementary motor area,” Experimental Brain Research, vol. 91, no. 3, pp. 396–407, 1992. View at Google Scholar · View at Scopus
  31. B. Elahi, B. Elahi, and R. Chen, “Effect of transcranial magnetic stimulation on parkinson motor function—systematic review of controlled clinical trials,” Movement Disorders, vol. 24, no. 3, pp. 357–363, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Berardelli, J. C. Rothwell, P. D. Thompson, and M. Hallett, “Pathophysiology of bradykinesia in parkinson's disease,” Brain, vol. 124, no. 11, pp. 2131–2146, 2001. View at Google Scholar · View at Scopus
  33. A. P. Georgopoulos, J. Ashe, N. Smyrnis, and M. Taira, “The motor cortex and the coding of force,” Science, vol. 256, no. 5064, pp. 1692–1695, 1992. View at Google Scholar · View at Scopus
  34. A. Pascual-Leone, J. Valls-Sole, E. M. Wassermann, and M. Hallett, “Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex,” Brain, vol. 117, no. 4, pp. 847–858, 1994. View at Google Scholar · View at Scopus
  35. A. Pascual-Leone, J. Valls-Solé, J. P. Brasil-Neto, A. Cammarota, J. Grafman, and M. Hallett, “Akinesia in Parkinson's disease. II. Effects of subthreshold repetitive transcranial motor cortex stimulation,” Neurology, vol. 44, no. 5, pp. 892–898, 1994. View at Google Scholar · View at Scopus
  36. A. P. Strafella, J. H. Ko, and O. Monchi, “Therapeutic application of transcranial magnetic stimulation in Parkinson's disease: the contribution of expectation,” NeuroImage, vol. 31, no. 4, pp. 1666–1672, 2006. View at Publisher · View at Google Scholar · View at Scopus