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Parkinson’s Disease
Volume 2014, Article ID 260485, 5 pages
Research Article

Independent Validation of the SEND-PD and Correlation with the MDS-UPDRS Part IA

1Clinical Laboratory of Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery, La Fama, 14269 Mexico City, Mexico
2Movement Disorders Clinic, National Institute of Neurology and Neurosurgery, 14269 Mexico City, Mexico
3National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, 30201 Madrid, Spain

Received 2 September 2014; Revised 7 October 2014; Accepted 10 October 2014; Published 23 October 2014

Academic Editor: Heinz Reichmann

Copyright © 2014 Mayela Rodríguez-Violante et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Neuropsychiatric symptoms in Parkinson’s disease can be assessed by the MDS-UPDRS part IA. The Scale for Evaluation of Neuropsychiatric Disorders in Parkinson’s disease (SEND-PD) has been recently developed to assess the severity of some neuropsychiatric symptoms. The objective of this study is to compare the performance of the SEND-PD with the corresponding items of the MDS-UPDRS part IA. Methods. Patients with Parkinson’s disease were evaluated using the MDS-UPDRS and the SEND-PD by independent raters. Partial SEND-PD and neuropsychiatric MDS-UPDRS part IA were constructed with equivalent items for comparison. Results. A total of 260 consecutive patients were included. Overall, 61.2% of the patients did not report any psychotic symptom and 83.5% did not report any ICD symptom. On the other hand, 78.5% of the patients did report at least one symptom related to apathy, depression, or anxiety. The partial SEND-PD score was (range from 0 to 16). The neuropsychiatric MDS-UPDRS part IA score was (range from 0 to 14). The correlation coefficient between corresponding items ranged from 0.67 to 0.98 and between both summary indexes was (all, ). Conclusion. A high association between equivalent items of the SEND-PD and the MDS-UPDRS was found.