Research Article
Trends in Antiparkinsonian Medication Use in New Zealand: 1995–2011
Table 2
Defined daily doses per 1000 inhabitants per day of antiparkinsonian medications prescribed to New Zealand outpatients (1995–2011).
| | 1995 | 1996 | 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | Change (%) |
| Total dopaminergic agents | 1.76 | 1.53 | 1.53 | 1.48 | 1.50 | 1.50 | 1.50 | 1.48 | 1.52 | 1.52 | 1.59 | 1.71 | 1.82 | 1.92 | 1.97 | 2.05 | 2.11 | 19.6 | L-dopa total | 0.78 | 0.74 | 0.82 | 0.84 | 0.91 | 0.95 | 0.98 | 0.99 | 1.04 | 1.05 | 1.11 | 1.15 | 1.19 | 1.24 | 1.28 | 1.34 | 1.38 | 76.9 | Madopar | 0.30 | 0.28 | 0.30 | 0.31 | 0.34 | 0.35 | 0.35 | 0.34 | 0.34 | 0.32 | 0.33 | 0.33 | 0.32 | 0.31 | 0.31 | 0.30 | 0.30 | −0.4 | Sinemet | 0.48 | 0.46 | 0.52 | 0.52 | 0.57 | 0.60 | 0.63 | 0.65 | 0.70 | 0.72 | 0.77 | 0.82 | 0.87 | 0.93 | 0.96 | 1.01 | 1.07 | 121.7 | Sindopa | | | | <0.001 | <0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | <0.01 | <0.01 | 0.01 | 0.02 | 0.02 | 9536.4 | Amantadine | 0.04 | 0.04 | 0.05 | 0.06 | 0.07 | 0.08 | 0.09 | 0.10 | 0.11 | 0.12 | 0.13 | 0.13 | 0.15 | 0.16 | 0.17 | 0.17 | 0.19 | 350.5 | COMTIs total | | | | 0.02 | 0.05 | 0.04 | 0.04 | 0.03 | 0.03 | 0.03 | 0.03 | 0.05 | 0.07 | 0.08 | 0.09 | 0.10 | 0.10 | 326.0 | Tolcapone | | | | 0.02 | 0.05 | 0.04 | 0.04 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.02 | 0.02 | 0.01 | 0.01 | 0.02 | −33.8 | Entacapone | | | | | | | | | | | <0.01 | 0.03 | 0.05 | 0.06 | 0.07 | 0.08 | 0.09 | 3759.6 | Dopamine agonist total | 0.35 | 0.29 | 0.28 | 0.25 | 0.23 | 0.22 | 0.21 | 0.20 | 0.20 | 0.19 | 0.19 | 0.25 | 0.29 | 0.31 | 0.31 | 0.32 | 0.33 | −6.2 | Apomorphine | <0.001 | <0.001 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | 0.01 | 98403.2 | Bromocriptine | 0.31 | 0.25 | 0.23 | 0.20 | 0.18 | 0.16 | 0.15 | 0.13 | 0.13 | 0.11 | 0.10 | 0.09 | 0.08 | 0.06 | 0.05 | 0.04 | 0.04 | −88.8 | Lisuride | 0.04 | 0.04 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.04 | 0.04 | 0.04 | 0.04 | 0.03 | 0.03 | 0.03 | −30.3 | Pergolide | <0.001 | 0.01 | 0.01 | 0.01 | 0.01 | 0.02 | 0.03 | 0.04 | 0.04 | 0.04 | 0.04 | 0.03 | 0.02 | 0.01 | 0.01 | 0.01 | 0.01 | 2477.3 | Ropinirole | | | | | | | | | | | 0.01 | 0.10 | 0.15 | 0.19 | 0.21 | 0.24 | 0.25 | 3349.8 | Selegiline | 0.59 | 0.46 | 0.38 | 0.31 | 0.25 | 0.21 | 0.18 | 0.15 | 0.14 | 0.13 | 0.13 | 0.12 | 0.12 | 0.12 | 0.13 | 0.12 | 0.11 | −81.7 | Anticholinergic total | 1.40 | 1.30 | 1.29 | 1.23 | 1.23 | 1.17 | 1.08 | 0.99 | 0.89 | 0.81 | 0.81 | 0.79 | 0.77 | 0.75 | 0.74 | 0.73 | 0.72 | −48.6 | Benzotropine | 1.11 | 1.04 | 1.04 | 0.99 | 1.00 | 0.95 | 0.88 | 0.81 | 0.71 | 0.63 | 0.64 | 0.63 | 0.62 | 0.61 | 0.60 | 0.60 | 0.59 | −46.4 | Orphenadrine | 0.15 | 0.13 | 0.13 | 0.12 | 0.12 | 0.11 | 0.11 | 0.09 | 0.09 | 0.08 | 0.08 | 0.07 | 0.07 | 0.06 | 0.06 | 0.05 | 0.05 | −64.4 | Procyclidine | 0.14 | 0.13 | 0.13 | 0.12 | 0.11 | 0.11 | 0.10 | 0.09 | 0.09 | 0.10 | 0.09 | 0.09 | 0.08 | 0.08 | 0.08 | 0.08 | 0.07 | −48.7 |
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COMTIs: catechol-o-methyl transferase inhibitors; L-dopa: levodopa.
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