Minimal Clinically Important Difference in Parkinson’s Disease as Assessed in Pivotal Trials of Pramipexole Extended Release

Table 5

Spearman correlation coefficients between PGI-I/CGI-I and changes in UPDRS scores and OFF time in patients with early PD and advanced PD.

Global improvement	Early PD			Advanced PD
	UPDRS II	UPDRS III	UPDRS II+III	UPDRS II	UPDRS III	UPDRS II+III	UPDRS II ON	UPDRS II OFF	OFF time (hrs)
CGI-I	0.42	0.51	0.54	0.33	0.4	0.42	0.19	0.36	0.31
PGI-I	0.35	0.34	0.39	0.31	0.3	0.34	0.21	0.32	0.27

PGI-I: Patient-rated Global Impression of Improvement; CGI-I: Clinician-rated Global Impression of Improvement.