Dopamine Cytotoxicity Involves Both Oxidative and Nonoxidative Pathways in SH-SY5Y Cells: Potential Role of Alpha-Synuclein Overexpression and Proteasomal Inhibition in the Etiopathogenesis of Parkinson's Disease
Figure 2
Effect of DA on mitochondrial functions in SH-SY5Y cells. SH-SY5Y cells were incubated without or with DA (400 μM) for 24 h in the absence or presence of NAC (2.5 mM) and (a) mitochondrial membrane potential and (b) intracellular ATP content were measured as described in Section 3. Values are the means ± SD of six observations. Statistically significant differences () exist among the groups as shown by asterisks (*) (in (a), = 353.56, ; in (b), = 67.39, ).
