Dopamine Cytotoxicity Involves Both Oxidative and Nonoxidative Pathways in SH-SY5Y Cells: Potential Role of Alpha-Synuclein Overexpression and Proteasomal Inhibition in the Etiopathogenesis of Parkinson's Disease
Figure 4
Effect of DA on proteasomal activity in SH-SY5Y cells. Proteasomal activity was measured in SH-SY5Y cells incubated without or with DA (400 μM) for 24 h in the presence or absence of NAC (2.5 mM) as detailed in Section 3. Values (expressed as percentage of the control) are the means ± SD of five observations. Statistically significant differences exist ( = 356.38, ) between the groups as shown by asterisks (*).
