Dopamine Cytotoxicity Involves Both Oxidative and Nonoxidative Pathways in SH-SY5Y Cells: Potential Role of Alpha-Synuclein Overexpression and Proteasomal Inhibition in the Etiopathogenesis of Parkinson's Disease
Figure 5
Effect of lactacystin on SH-SY5Y cell-viability. SH-SY5Y cells were treated without (control) or with lactacystin (5 μM) for 24 h followed by the measurement of cell viability by (a) trypan blue method and (b) activity of released LDH, as described in Section 3. Values are the means ± SD of six observations. Student’s -test, paired, shows significant difference () in the cell viability between the treated group (M = 30.49, SD = 2.69) and the control group (M = 4.01, SD = 1.72); (5) = 24.23, as shown by asterisks (*).
